Author Information

D. D. Kratzer
R. C. Littell

Abstract

Kratzer and Ash(1996) presented Experimentation Science as a process to accomplish the Scientific Method with a complete protocol including relevant statistical design and analyses The first principal to sound Experimentation Science is the principle of Relevance. This is a case study primarily of Relevance in Experimentation Science. In our consulting work we found a so called “performance” design as not relevant because of the use of null hypothesis testing to promote a concept of equivalence. The best alternative involves equivalence testing, more replication and representative-ness. Secondly we found a dose response design for two products where non-linear asymptotic regression is misused in applying Bioassay techniques to estimate a single relative biological efficacy (RBV) because the basic assumption of sameness of mathematical form does not hold. We offer a relevant model which involves predicted differences in the relevant zone of commercial use (Vazquez- Añón, M et al, 2006b, Gonzales-Esquerra et al, 2007).

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Apr 30th, 10:00 AM

APPROPRIATE STATISTICAL METHODS FOR COMPARING SOURCES OF NUTRITIONAL METHIONINE

Kratzer and Ash(1996) presented Experimentation Science as a process to accomplish the Scientific Method with a complete protocol including relevant statistical design and analyses The first principal to sound Experimentation Science is the principle of Relevance. This is a case study primarily of Relevance in Experimentation Science. In our consulting work we found a so called “performance” design as not relevant because of the use of null hypothesis testing to promote a concept of equivalence. The best alternative involves equivalence testing, more replication and representative-ness. Secondly we found a dose response design for two products where non-linear asymptotic regression is misused in applying Bioassay techniques to estimate a single relative biological efficacy (RBV) because the basic assumption of sameness of mathematical form does not hold. We offer a relevant model which involves predicted differences in the relevant zone of commercial use (Vazquez- Añón, M et al, 2006b, Gonzales-Esquerra et al, 2007).