Author Information

Weixing Song

Abstract

The dosage levels measured in direct bioassays are often contaminated with measurement errors, which are usually neglected in the statistical inference. This paper proposes several estimation procedures for the relative potencies in direct bioassays taking the measurement errors into account. Asymptotic theories are developed for constructing the confidence intervals. Numerical simulations are also included to compare different estimation procedures.

Keywords

Relative Potency; Bioassay; Errors-in-Variables Model; Deconvolution Kernel Estimator; Simulation Extrapolation; Empirical Likelihood

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Apr 19th, 9:00 AM

RELATIVE POTENCY ESTIMATION IN DIRECT BIOASSAY WITH MEASUREMENT ERRORS*

The dosage levels measured in direct bioassays are often contaminated with measurement errors, which are usually neglected in the statistical inference. This paper proposes several estimation procedures for the relative potencies in direct bioassays taking the measurement errors into account. Asymptotic theories are developed for constructing the confidence intervals. Numerical simulations are also included to compare different estimation procedures.