Effects of Choline on Neutrophil Function and Inflammation in Growing Cattle with Modulated Methyl Group Status

Authors

M. S. Grant, Kansas State UniversityFollow
H. D. Aufdemberge, Kansas State UniversityFollow
B. J. Bradford, Department of Animal Science, Michigan State University, East Lansing, MI
L. K. Mamedova, Department of Animal Science, Michigan State University, East Lansing, MI
E. C. Titgemeyer, Kansas State University, ManhattanFollow

Keywords

methyl groups, choline, immune function

Abstract

Objective: This study was conducted to evaluate the effects of supplemental choline in combination with guanidinoacetic acid or creatine on immune cell function and inflammation in growing cattle.

Study Description: Six ruminally-cannulated Holstein steers (321 lb) were utilized in an experiment where each steer received each of six treatments. Treatments were given via abomasal infusion of a 0 or 5 g/day of supplemental choline, and either a saline solution (control); 15 g/day guanidinoacetic acid; or 16.8 g/day of creatine, with all treatment combinations represented. Steers were fed a corn-based diet. Blood was collected during each period to measure neutrophil function, plasma haptoglobin, and plasma antioxidant potential.

Bottom line: Supplementing steers with 5 g/day of choline tended to reduce plasma haptoglobin concentrations, suggesting that choline reduced systemic inflammation.

Recommended Citation

Grant, M. S.; Aufdemberge, H. D.; Bradford, B. J.; Mamedova, L. K.; and Titgemeyer, E. C. (2021) "Effects of Choline on Neutrophil Function and Inflammation in Growing Cattle with Modulated Methyl Group Status," Kansas Agricultural Experiment Station Research Reports: Vol. 7: Iss. 1. https://doi.org/10.4148/2378-5977.8033