antioxidant status, growth, nursery pigs, selenium


A total of 3,888 pigs (337 × 1050, PIC; initially 13.1 ± 0.10 lb) were used in a 42-d trial. At the time of placement, pens of pigs were weighed and allotted to 1 of 3 dietary treatments in a randomized complete block design with blocking structure including sow farm origin, date of entry into the facility, and average pen body weight. A total of 144 pens were used with 72 double-sided 5-hole stainless steel fence line feeders, with feeder serving as the experimental unit. For each feeder, 1 pen contained 27 gilts and 1 pen contained 27 barrows. There were 24 replicates per dietary treatment. Diets were fed in three phases and all contained 0.3 ppm added selenium. A common phase 1 diet contained added selenium from sodium selenite and was fed in pelleted form to all pigs for approximately 7 d. Three selenium sources [sodium selenite; selenium yeast; and hydroxy-selenomethionine (OH-SeMet)] were used to formulate 3 experimental diets in meal form for phase 2 and phase 3. From d 0 to 7, there was marginally significant evidence (P = 0.097) of a difference in ADFI, although no significant pairwise differences were observed (P > 0.05). There were no additional differences in growth performance between treatments during the d 0 to 7 period. Clinical disease attributed to Streptococcus suis was observed within the trial, and water soluble antimicrobial therapy was administered to all treatment groups. From d 7 to 42, pigs fed OH-SeMet tended to have decreased ADG (P < 0.10) and had increased (P < 0.05) serum and tissue selenium concentration compared to other treatments. There was marginally significant evidence of a source × day interaction for T-AOC where the numerical increase over time was less for the OH-SeMet compared to sodium selenite or selenium yeast treatments. There was no difference (P > 0.05) in antioxidant status as measured by serum GSH-Px or TBARS assay between treatments. In summary, compared to sodium selenite and selenium yeast, OH-SeMet had greater bioavailability as indicated by increased serum and tissue selenium concentration; however, antioxidant status was similar between treatments, and OH-SeMet tended to reduce growth performance compared with pigs fed sodium selenite.

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This work is licensed under a Creative Commons Attribution 4.0 License.