Why are nit-2 transformants of Aspergillus nidulans partially derepressed?

Authors

M. A. Davis, University of Melbourne
M. J. Hynes, University of Melbourne

Abstract

The major nitrogen metabolite repression control genes of Aspergillus nidulans and Neurospora crassa are the areA and nit-2 genes respectively. Both genes encode transcriptional activators with highly conserved C2-X17-C2 zinc finger DNA binding domains which recognize similar WGATAR DNA sequences (Kudla et al., 1990 EMBO J. 9: 1355-1364; Fu and Marzluf, 1990 Proc. Natl. Acad. Sci USA 87: 5331-5335). We have shown previously that the N. crassa nit-2 gene can fully complement an areA loss-of-function mutation in A. nidulans, restoring growth on a wide variety of nitrogen sources. However, the nit-2 transformants are partially derepressed (Davis and Hynes, 1987 Proc. Natl. Acad. Sci. USA 84: 3753-3757).

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Recommended Citation

Davis, M. A., and M.J. Hynes (1997) "Why are nit-2 transformants of Aspergillus nidulans partially derepressed?," Fungal Genetics Reports: Vol. 44, Article 6. https://doi.org/10.4148/1941-4765.1274