The Clock affecting 1 mutation of Neurospora is a recurrence of the frq⁷ mutation7

Authors

Michael A. Collett, Dartmouth Medical School
Jennifer J. Loros, Dartmouth Medical School
Jay C. Dunlap, Dartmouth Medical School

Abstract

The clock affecting-1 (cla-1) mutation of Neurospora crassa increases the period and decreases temperature compensation of the circadian rhythm, and was thought to define an uncloned gene with a possible role in the Neurospora clock. This defect, thought to be due to a translocation, was associated with a slow growth rate and a period of about 27 h at 25cla-1 and found the growth rate and period defects to be due to linked independent mutations. The translocation was not the cause of the long period. The csp-1 mutation, present in the original cla-1 strain, had a period shortening effect, thus cla-1 strains lacking csp-1 had a period length similar to that of frequency⁷ (frq⁷). The cla-1 period defect mapped to the frq locus, and sequencing of frq revealed cla-1 to be a re-isolation of frq⁷.

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Recommended Citation

Collett, M. A., J.J. Loros, and J.C. Dunlap (2001) "The Clock affecting 1 mutation of Neurospora is a recurrence of the frq⁷ mutation7," Fungal Genetics Reports: Vol. 48, Article 3. https://doi.org/10.4148/1941-4765.1168