Various genotypes can result in round ascospores in N. crassa (Mitchell 1966 Neurospora Newsl. 10:6; Barry et al. 1972 Neurospora Newsl. 19:17). I have observed that round ascospores can also originate in crosses where one parent is the apparent breakdown of a partial diploid heterozygous at the heterokaryon incompatibility locus het-5. The breakdown may remove one of the duplicated chromosome segments carrying a het-5 allele and possibly extend past the duplication and affect the nearby Round spore locus (R).

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