Four choline-requiring mutants of Neurospora crassa have been identified genetically. The chol-1 and chol-2 mutants are impaired in phosphatidylcholine biosynthesis. Phospholipid synthesis is also impaired in the inl and un-17 mutants; the inl mutant cannot synthesize inositol phospholipids. Defects in phospholipid biosynthesis are reported here for three previously uncharacterized mutants, un-17, chol-3 and chol-4.
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"Characterization of un-17, chol-3 and chol-4, phospholipid biosynthetic mutants of Neurospora crassa,"
Fungal Genetics Reports:
Vol. 47, Article 19.