Student Major/Year in School
Nutritional Sciences, first year
Faculty Mentor Information
Stefan H. Bossmann, Department of Chemistry, College of Arts and Sciences
Abstract
Developing a Technique Using Peptide and Dye Synthesis for Cancer Research
Vanessa Hernandez, Obdulia Covarrubias Zambrano, Stefan H. Bossmann
Department of Chemistry, College of Arts and Sciences, Kansas State University
Cancer occurs when a mutated single cell continues to divide uncontrollably, developing into one of the 200 different cancer types. Cancer is the second leading cause of death in the United States, with approximately 1.8 million new cases occurring this year. Current cancer detection and treatment techniques are costly and not optimal, due to the lack of cancer specificity as well as early detection achieved in some cancer types. This project focuses on the synthesis development of peptides and fluorescent dyes that could be used for cancer research.The solid phase peptide synthesis procedure as well as cyanine 7 synthesis will be discussed here. Cyanine 7 is a blue fluorescent dye synthesized and used to label peptides, so they can be used to quantify protease levels as an aim for cancer detection technique. Establishing a well synthesized peptide will help us to advance for better cancer detection and treatment techniques.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Recommended Citation
Hernandez, Vanessa (2019). "Developing a Technique Using Peptide and Dye Synthesis for Cancer Research," Kansas State University Undergraduate Research Conference. https://newprairiepress.org/ksuugradresearch/2019/posters/41
Developing a Technique Using Peptide and Dye Synthesis for Cancer Research
Developing a Technique Using Peptide and Dye Synthesis for Cancer Research
Vanessa Hernandez, Obdulia Covarrubias Zambrano, Stefan H. Bossmann
Department of Chemistry, College of Arts and Sciences, Kansas State University
Cancer occurs when a mutated single cell continues to divide uncontrollably, developing into one of the 200 different cancer types. Cancer is the second leading cause of death in the United States, with approximately 1.8 million new cases occurring this year. Current cancer detection and treatment techniques are costly and not optimal, due to the lack of cancer specificity as well as early detection achieved in some cancer types. This project focuses on the synthesis development of peptides and fluorescent dyes that could be used for cancer research.The solid phase peptide synthesis procedure as well as cyanine 7 synthesis will be discussed here. Cyanine 7 is a blue fluorescent dye synthesized and used to label peptides, so they can be used to quantify protease levels as an aim for cancer detection technique. Establishing a well synthesized peptide will help us to advance for better cancer detection and treatment techniques.
