ORCID
orcid.org/0000-0002-9150-169X
Keywords
Swine day, 2002; Kansas Agricultural Experiment Station contribution; no. 03-120-S; Report of progress (Kansas State University. Agricultural Experiment Station and Cooperative Extension Service); 897; Pigs; Salmonella; Muscle; IGF-1, IGFBP-3; Swine
Abstract
Eighteen pigs (initial weight 25 lb and approximately 5 wk of age) were used in a 14-d trial to determine the effects of an acute Salmonella enterica serotype typhimurium (ST) disease challenge on both circulating insulinlike growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) and steady-state IGF-1 and IGFBP-3 mRNA levels in skeletal muscle. Muscle biopsies and blood samples were obtained from all pigs on d 0, 3, 7, and 14 relative to ST-challenge. Results suggest that an acute ST-challenge decreased circulating IGF-1 levels on d 3 and 7 but did not affect circulating IGFBP-3 concentrations. Additionally, ST-challenge had no effect on steady-state IGF-1 and IGFBP-3 mRNA levels in skeletal muscle following the onset of disease. These data suggest that an acute enteric disease insult can lower circulating IGF-1 but more chronic conditions may be necessary to affect local IGF-1 levels in skeletal muscle. Additionally, the increased muscle IGF-1 mRNA without increased IGFBP-3 levels on d 14 most likely results in increased IGF-1 synthesis that contributes to circulating IGF-1 concentrations.; Swine Day, Manhattan, KS, November 14, 2002
Recommended Citation
Johnson, B J.; Kayser, J P.; Dunn, J D.; Waylan, A T.; Drtiz, S S.; Nietfeld, Jerome C.; and Minton, J Ernest
(2002)
"Effects of an acute enteric disease challenge on IGF-1 and IGFBP-3 gene expression in porcine skeletal muscle (2002),"
Kansas Agricultural Experiment Station Research Reports:
Vol. 0:
Iss.
10.
https://doi.org/10.4148/2378-5977.6771
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