methyl groups, choline, immune function


Objective: This study was conducted to evaluate the effects of supplemental choline in combination with guanidinoacetic acid or creatine on immune cell function and inflammation in growing cattle.

Study Description: Six ruminally-cannulated Holstein steers (321 lb) were utilized in an experiment where each steer received each of six treatments. Treatments were given via abomasal infusion of a 0 or 5 g/day of supplemental choline, and either a saline solution (control); 15 g/day guanidinoacetic acid; or 16.8 g/day of creatine, with all treatment combinations represented. Steers were fed a corn-based diet. Blood was collected during each period to measure neutrophil function, plasma haptoglobin, and plasma antioxidant potential.

Bottom line: Supplementing steers with 5 g/day of choline tended to reduce plasma haptoglobin concentrations, suggesting that choline reduced systemic inflammation.

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Beef Science Commons


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